Elephant Endotheliotropic Herpesviruses EEHV 1 A , EEHV 1 B and EEHV 2 3 from Cases of Hemorrhagic Disease are Highly Diverged from Other 4 Mammalian
نویسندگان
چکیده
6 Laura K. Richman , Jian-Chao Zong , Erin M. Latimer 2 , Justin Lock , Robert 7 Fleischer , Sarah Y. Heaggans 1 and Gary S. Hayward 1# 8 9 10 (1) Viral Oncology Program, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School 11 of Medicine, Baltimore, Maryland 12 and 13 (2) National Elephant Herpesvirus Laboratory, Pathology Department, and (3) Center for Conservation Ecology 14 and Genetics, Smithsonian’s National Zoo, Washington, DC. 15 16 17
منابع مشابه
Comparative Genome Analysis of Four Elephant Endotheliotropic 4 Herpesviruses EEHV 3 , EEHV 4 , EEHV 5 and EEHV 6 from Cases of 5 Hemorrhagic
7 Jian-Chao Zong, Erin M. Latimer, Simon Y. Long, Laura K. Richman, Sarah Y. Heaggans 8 and 9 Gary S. Hayward 10 11 12 (1) Viral Oncology Program, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of 13 Medicine, Baltimore, Maryland and 14 (2) National Elephant Herpesvirus Laboratory, Pathology Department, Smithsonian’s National Zoo, 15 Washington, DC. 16 17 Running Title:...
متن کاملIdentification of shedders of elephant endotheliotropic herpesviruses among Asian elephants (Elephas maximus) in Switzerland
Elephants, particularly Asian (Elephas maximus), are threatened by lethal elephant hemorrhagic disease (EHD) due to elephant endotheliotropic herpesviruses (EEHV). At least five of seven known EEHV types have been associated to EHD, with types 1, 4, and 5 predominantly affecting Asian elephants. In Switzerland, at least three Asian elephants have been lost due to EHD but nothing is known about ...
متن کاملAsian Elephant T Cell Responses to Elephant Endotheliotropic Herpesvirus
Elephant Endotheliotropic Herpesvirus (EEHV) can cause lethal hemorrhagic disease in juvenile Asian elephants, an endangered species. One hypothesis to explain this vulnerability of some juvenile elephants is that they fail to mount an effective T cell response to the virus. To our knowledge, there have been no studies of Asian elephant T cell responses to EEHV. To address this deficiency, we v...
متن کاملComplete genome sequences of elephant endotheliotropic herpesviruses 1A and 1B determined directly from fatal cases.
A highly lethal hemorrhagic disease associated with infection by elephant endotheliotropic herpesvirus (EEHV) poses a severe threat to Asian elephant husbandry. We have used high-throughput methods to sequence the genomes of the two genotypes that are involved in most fatalities, namely, EEHV1A and EEHV1B (species Elephantid herpesvirus 1, genus Proboscivirus, subfamily Betaherpesvirinae, famil...
متن کاملA novel antigen capture ELISA for the specific detection of IgG antibodies to elephant endotheliotropic herpes virus
BACKGROUND Elephants are classified as critically endangered animals by the International Union for Conservation of Species (IUCN). Elephant endotheliotropic herpesvirus (EEHV) poses a large threat to breeding programs of captive Asian elephants by causing fatal haemorrhagic disease. EEHV infection is detected by PCR in samples from both clinically ill and asymptomatic elephants with an active ...
متن کامل